Isotope-Labeled Compounds
Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time.
MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.
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Isotope-Labeled Compounds Related Products (11058)
Related Products (11058)
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Octreotide-d8 TFA
0 ImagesCat. No.: HY-P0036SSynonyms: SMS 201-995-d8 TFAOctreotide-d8 (SMS 201-995-d8) TFA is the deuterium labeled Octreotide TFA. Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide (SMS 201-995) can bind to the somatostatin receptor and mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide (SMS 201-995) has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly.
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Dihydroartemisinin-d
0 ImagesCat. No.: HY-N0176S6CAS No.: 252043-36-0Synonyms: Dihydroqinghaosu-d; β-Dihydroartemisinin-d; Artenimol-dDihydroartemisinin-d (Dihydroqinghaosu-d) is the d-labeled Dihydroartemisinin (HY-N0176). Dihydroartemisinin is an orally active metabolite of rtemisinin (HY-B0094) and antimalarial agent. Dihydroartemisinin induces Autophagy by inhibiting NF-κB activation. Dihydroartemisinin promotes ROS accumulation. Dihydroartemisinin exhibits anticancer activity in esophageal cancer cells. Dihydroartemisinin shows schistosomicidal activity against juvenile and adult worms of Schistosoma japonicum, reduces worm burden, and displays antiparasitic activity. Dihydroartemisinin can be used in research related to multiple myeloma, promyelocytic leukemia, esophageal cancer, and Schistosoma japonicum infection.
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DPA-714-d10
0 ImagesCat. No.: HY-122607SDPA-714-d10 is the deuterium labeled DPA-714 (HY-122607). DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. 18FDPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model.
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Pegcetacoplan-13C3,15N TFA
0 ImagesCat. No.: HY-P3252ASPegcetacoplan-13C3,15N TFA is the 13C- and 15N-labeled Pegcetacoplan TFA. Pegcetacoplan is a pegylated complement C3/C3b inhibitor. Pegcetacoplan acts by specifically binding to and inhibiting C3 and C3b, thereby suppressing the complement cascade at its proximal stage. Pegcetacoplan is not a known inhibitor or inducer of CYP450 isoenzymes. Pegcetacoplan can be used for the research of complement-mediated diseases, including paroxysmal nocturnal hemoglobinuria (PNH) and age-related macular degeneration (AMD).
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GDC-0575-d4
0 ImagesCat. No.: HY-112167SSynonyms: ARRY-575-d4; RG7741-d4GDC-0575-d4 (ARRY-575-d4) is the deuterium labeled GDC-0575 (HY-112167). GDC-0575 (ARRY-575, RG7741) is a highly-selective oral small-molecule Chk1 inhibitor with an IC50 of 1.2 nM.
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3-(1-Nitrosopyrrolidin-2-yl)pyridine-13C6
0 ImagesCat. No.: HY-W768044CAS No.: 2726380-44-33-(1-Nitrosopyrrolidin-2-yl)pyridine-13C6 is the 13C-labeled 3-(1-Nitrosopyrrolidin-2-yl)pyridine (HY-W189682). 3-(1-Nitrosopyrrolidin-2-yl)pyridine is a major tobacco-specific nitrosamine.
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(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-aspartic acid-15N
0 ImagesCat. No.: HY-W837593CAS No.: 287484-33-7(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-aspartic acid-15N is the 15N-labeled (((9H-Fluoren-9-yl)methoxy)carbonyl)-L-aspartic acid (HY-W013182). (((9H-Fluoren-9-yl)methoxy)carbonyl)-L-aspartic acid is an aspartic acid derivative.
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Leucic acid-13C
0 ImagesCat. No.: HY-30216ASSynonyms: α-Hydroxyisocaproic acid-13CLeucic acid-13C (α-Hydroxyisocaproic acid-13C) is the 13C-labeled Leucic acid (HY-30216A). Leucic acid is an amino acid metabolite.
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Exatecan Intermediate 1-d2
0 ImagesCat. No.: HY-42487S1CAS No.: 3061737-78-5Exatecan Intermediate 1-d2 is the deuterium labeled Exatecan Intermediate 1 (HY-42487). Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631). Exatecan is a DNA topoisomerase I inhibitor with anticancer effects.
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Tuvusertib-d3
0 ImagesCat. No.: HY-111451SSynonyms: M1774-d3; ATR inhibitor 1-d3Tuvusertib-d3 (M1774-d3) is the deuterium labeled Tuvusertib (HY-111451). Tuvusertib (M1774; ATR inhibitor 1) is a selective and orally active ATR inhibitor with a Ki value below 1 μΜ.
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Decanoyl-L-carnitine-d19
0 ImagesCat. No.: HY-135035S1Synonyms: (-)-Decanoylcarnitine-d19Decanoyl-L-carnitine-d19 ((-)-Decanoylcarnitine-d19> is the deuterium labeled Decanoyl-L-carnitine (HY-135035). Decanoyl-L-carnitine ((-)-Decanoylcarnitine) is an endogenous metabolite. Decanoyl-L-carnitine can be used as a serum metabolic biomarkers as indicators in the progression of intravenous leiomyomatosis.
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DPPC-13C
0 ImagesCat. No.: HY-109506S10Synonyms: 129Y83-13CDPPC-13C3 (129Y83-13C) is the 13C-labeled DPPC (HY-109506). DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice.
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Boc-L-Valine-15N
0 ImagesCat. No.: HY-W002300S1CAS No.: 141509-91-3
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Metformin-13C2 (hydrochloride)
0 ImagesCat. No.: HY-B0627S1Synonyms: 1,1-Dimethylbiguanide-13C2 hydrochlorideMetformin-13C2 (1,1-Dimethylbiguanide-13C2) hydrochloride is the 13C-labeled Metformin hydrochloride (HY-17471A). Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo.
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Luvometinib-d
0 ImagesCat. No.: HY-159846SSynonyms: FCN-159-dLuvometinib-d (FCN-159-d) is the deuterated-labeled Luvometinib (HY-159846). Luvometinib is an orally potent MEK1/2 inhibitor. Luvometinib selectively blocks the MAPK signaling pathway by forming a ternary complex with MEKase and ATP, thereby reducing the phosphorylation level of ERK. Luvometinib induces cell cycle arrest and apoptosis, and inhibits cancer cell proliferation. Luvometinib can be used in relevant research on various solid tumors including melanoma, non-small cell lung cancer, colon cancer, and acute myeloid leukemia.
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Oxytocin-13C6,15N TFA
0 ImagesCat. No.: HY-17571SSynonyms: α-Hypophamine-13C6,15N TFA; Oxytocic hormone-13C6,15N TFAOxytocin-13C6,15N (α-Hypophamine-13C6,15N) TFA is the 13C- and 15N-labeled Oxytocin TFA. Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma.
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Sucrose-13C12
0 ImagesCat. No.: HY-W753763CAS No.: 1217464-95-3Synonyms: D-(+)-Saccharose-13C12Sucrose-13C12 (D-(+)-Saccharose-13C12) is the 13C-labeled Sucrose (HY-B1779). Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose can be applied in some animal models, including metabolic disease, obesity, diet on preference, and diabetes, et al.
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Banoxantrone-d12
0 ImagesCat. No.: HY-13562SCAS No.: 1562067-05-3Synonyms: AQ4N d12Banoxantrone-d12 is the deuterium labeled banoxantrone. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.
